Gene

chia.2

ID

ZDB-GENE-040426-2014

Name

chitinase, acidic.2

Symbol

chia.2 Nomenclature History

Previous Names

chia2 (1)
wu:fb61c11
zgc:55941
zgc:77889

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Description

Predicted to have chitin binding activity and chitinase activity. Predicted to be involved in chitin catabolic process. Predicted to localize to cytoplasm and extracellular region. Human ortholog(s) of this gene implicated in asthma and schizophrenia. Is expressed in gut and liver. Orthologous to several human genes including CHIT1 (chitinase 1); CHIA (chitinase acidic); and OVGP1 (oviductal glycoprotein 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

11 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With chia.2 Human Ortholog

No data available

Associated With chia.2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR001579	Glycosyl hydrolase family 18, active site
Domain	IPR001223	Glycoside hydrolase family 18, catalytic domain
Domain	IPR002557	Chitin binding domain
Family	IPR050314	Glycosyl Hydrolase Family 18
Homologous_superfamily	IPR017853	Glycoside hydrolase superfamily
Homologous_superfamily	IPR029070	Chitinase insertion domain superfamily
Homologous_superfamily	IPR036508	Chitin binding domain superfamily

Domain Details Per Protein

Protein	Length	Chitinase insertion domain superfamily	Chitin binding domain	Chitin binding domain superfamily	Glycoside hydrolase family 18, catalytic domain	Glycoside hydrolase superfamily	Glycosyl Hydrolase Family 18	Glycosyl hydrolase family 18, active site
UniProtKB:Q6P006 InterPro	470

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	chia.2-201 (1) Ensembl	Ensembl		1,762 nt	Select Tool ZFIN BLAST
mRNA	chia.2-202 (1) Ensembl	Ensembl		3,103 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations